What is XML?
Verbose, strict, and still holding up enormous amounts of the world - government feeds, financial messaging, publishing, office documents. JSON took the web from it, but anywhere with schemas and validators and twenty years of history, XML is what's on the wire.
What is XLSX?
A modern Excel workbook, which is really a zip full of XML. Unlike a CSV it knows what a number is, holds multiple sheets, and keeps formulas and formatting. It's what people mean when they say 'send me a spreadsheet'.